Technical Capabilities

复杂和多步骤合成

Thomas Swan提供各类复杂的多步骤合成功能。我们的目标是提供快速、灵活和保密的服务。以下列表详细介绍了我们目前的合成能力范围:

Polymerisations and Polymer Modification

More than 50 years industrial experience in a broad range of polymerisation technologies

Alkylations

Experience in using dimethyl sulfate as alkylation agents plus use of Friedel Crafts alkylation chemistry at up to 1000tpa capactiy

Nitrations

Dedicated facility for industrial applications

Aminations and Amidations

Dedicated and multipurpose plants capable of performing these chemistries

Halogenations

Commercial scale halogenation capacity to 500tpa with the capability for cGMP manufacture

Cyclisation

A broad range of capabilities including Diels Alder, primarily for household, health and personal care industries

Isomerisation

With the capacity to isomerise and isolate products by distillation

Sulphonation

Sulphonation of aromatic substrates and polyaromatic polymers

Maleinisation and Alder-ene

100tpa capacity at temperatures up to 270oc

Thiocyanation

25 years of experience in aromatic thiocyanation up to 500tpa

Oxidation

Commercial scale experience of a broad range of carbon and hetero atom oxidations

Diazotisations

Several years of experience of diazotisation including hair and personal care product applications

General technologies performed include

Amidation

Chlorination

Friedel Crafts

Hydrogenation

Amination

Cyclisation

Grignard

Isomerisation

Nitration

Oxidation

Polymerisation

Sulponation

Thiocyanation

Extensive downstream processing capabilities including:

Drying

Grinding and milling

Formulation

Distillation capabilities

Bulk storage

Advanced Processing Facilities

30多年来,Thomas Swan一直处于尖端创新工艺工程的前沿。目前的商业规模设施包括:

高温处理

在惰性条件下运行的商业规模的批量炉和连续炉,最高温度可达1000℃。这种多功能设备在最先进的制造环境中促进了许多专业技术,包括:

Chemical Vapour Deposition

(batch and continuous)

Gas-solid reactions

Gas-solid reactions and other specific reactions including:
i. Reductions and Oxidations
ii. Drying and Calcination
ii. Catalyst processing and activation

Pilot Scale Laboratories

多功能中试实验室不仅支持商业规模的操作,还便于在高度控制的条件下产生确定数量。设施包括:

Furnaces operating under inert conditions to 1000°C.

Low-temperature processing

Vacuum and Inert atmosphere heat treatments and mixing

Heat, vacuum and freeze drying processes

High-speed shear mixing / high throughput sonication

Liquid-solid reactions

i. Dissolution
ii. Controlled precipitation

Analytical Development Laboratories

Thomas Swan近期在分析开发服务方面投资了20万英镑,突显了我们重视执行分析开发和方法验证的程度。它与工艺开发完美同步,可确保所有项目均按时达成协议规范并安全交付。

我们广泛的内部表征工具包括:

,

GC

with FID detector, liquid and headspace injection techniques

GCMS

HPLC

with UV or Diode Array detectors

GPC

with Refractive Index Detector

Atomic Absorption

Raman Spectroscopy

TGA

ICP-OES

Scanning UV

Viscosity

(Cone & Plate, Brookfield and PRS)

Standard wet analysis

including auto-titration

Physical properties testing equipment

X-rite Colour Spectrophotometer

QUV

Tensile tester

Seal Strength tester

Friction tester

Impact tester

Conical Mandrel bend tester

Gel Strength tester

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